Age-Related Changes in Rabbit Lens Viscoelasticity measured using Optical Coherence Elastography
Hongqiu Zhang1, Manmohan Singh1, Fernando Zvietcovich1, Kirill V. Larin1,2, and Salavat R. Aglyamov3
1Department of Biomedical Engineering, University of Houston, 3517 Cullen Blvd., Room 2027, Houston, TX 77204, USA
2Molecular Physiology and Biophysics, Baylor College of Medicine, One Baylor Plaza, BCM335, Houston, TX 77030, USA
3Department of Mechanical Engineering, University of Houston, 4726 Calhoun Rd., Room N207., Houston, TX 77204, USA
Abstract
Lenticular biomechanical properties play a critical role in eye health and vision. The measurement of the viscoelastic properties may help better understandconditions such as presbyopia and cataract. In this study, focused acoustic radiation force (ARF) induced surface waves in young and mature rabbit lenses in situ. Phase-sensitive optical coherence elastography (OCE) system imaged the wave propagation, and the wave dispersion was quantified by spectral analysis. The results show that the dispersion of the ARF-induced elastic waves was different between the young (N=5) and mature (N=5) lenses. A Scholte wave model was used to estimate the viscoelastic properties of the lenses. Estimated Young’s moduli of the lenses were 7.74±1.56 kPa (young) and 17.16±2.16 kPa (mature), and the shear viscosity of the lenses were 0.55±0.04 Pa·s (young) and 0.87±0.13 Pa·s (mature). The Young’s moduli and shear viscosity were significantly different (P=0.13 and P=0.24, respectively). The results show that OCE could be useful for measuring the age-related changes in lenticular viscoelasticity in vivo for lens-related conditions.
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Hongqiu Zhang
University of Houston
United States
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