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Fluorescence Guided Procedures and Photodynamic Therapy in Neurosurgery

R. Sroka 1,2, H. Stepp 1,2 , N. Markwardt 1, C. Heckl 1, M. Aumiller 1, A. Rühm 1,2
1 Laser-Forschungslabor in LIFE Center, University Hospital, LMU-Munich, Germany
2 Department of Urology, University Hospital, LMU-Munich, Germany


This lecture gives an introduction about the application of photoactive drugs and their use for fluorescence guided resection, optical guided biopsy and photodynamic therapy in neurosurgery. Besides the medical needs, requests and boundary conditions the physics and technical research and developments will be presented aiming in clinical applications. Preliminary study results as well as the potential of optical dosimetry concepts based on light-tissue interaction and light-photosensitizer interaction are included summarizing the latest developments in this field.
Fluorescence in Neurosurgery
After description of the clinical needs in neurosurgery, and the possibilities of receiving a selective accumulation of the photosensitizer in the target tissue, the newest development of fluorescence detection techniques (e.g. fiber based, imaging) according with their limitations and potentials will be presented. The development of such technologies will be described based on simulations, phantom based experiments as well as on the influences of the optical properties of the tissue.
PDT in Neurosurgery
After description of PDT, the technological developments for sufficient illumination of resection cavities and tumor volumes will be presented. Regarding this, specific recommendations to the illumination systems should be fulfilled and their technical solutions are presented. Furthermore, the importance of optical feedback together with potential optical technological solutions will be described resulting in a dosimetry concept for clinical availability.


Ronald Sroka
Laser-Forschungslabor in LIFE Center, University Hospital, LMU-Munich, Germany


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