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ANALYSIS OF SPECTRAL CHARACTERISTICS OF COLLAGEN SOLUTIONS IN THZ SPECTRUM REGION

Anastasia I.Knyazkova,1,2, Olga P. Cherkasova,1,3, Yuri V. Kistenev,1, Alexey V. Borisov,1
1 Tomsk State University, Tomsk, Russia, 2 Institute of Atmospheric Optics SB RAS, Tomsk, Russia, 3 Institute of Laser Physics SB RAS, Novosibirsk, Russia


Abstract

In the region of terahertz (THz) frequencies, there are strong absorption lines of many substances, as well as the vibration frequencies of many biopolymers, which are sensitive to the geometric shape of the molecule, its environment and play an important role in biochemical reactions. The advantage of terahertz spectroscopic approaches is that they allow the measurement of amplitude and phase information, which are directly related to the absorption coefficient and refractive index of proteins. Morphological studies of dehydrated tissues (paraffin blocks) in the THz region of the spectrum show a good correlation with histological analysis. However, the use of fixation reagents when creating a histological preparation affects the structure and chemical properties of proteins. When examining biological samples, it is important to understand how formalin fixation can affect THz absorption spectra. The aim of this work is to analyze the spectral characteristics of collagen type 1 solutions in the THz spectral region in the frequency range 0.2-1.1 THz.
This work was performed within the frame partial financial support from the Russian Foundation for Basic Research (grant №20-32-90098) and carried out with partial support of a grant under the Decree of the Government of the Russian Federation No. 220 of 09 April 2010 (Agreement No. 075-15-2021-615 of 04 June 2021).


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Knyazkova Anastasia
Tomsk State University, Institute of Atmospheric Optics SB RAS
Russia

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