Silver nanoparticles modified with cyclodextrins for SERS analysis
Natalia E. Markina, Alexey V. Markin
Saratov State University, Saratov, Russia
Abstract
The aim of this report is the synthesis of silver nanoparticles modified with cyclodextrin molecules (AgNP@CDs) and their application in SERS-based analysis. AgNP@CDs were prepared using one-pot synthesis protocol based on the reduction and stabilization of AgNPs by CDs (α or β). The reduction of SERS signal in the presence of excess of CD molecules was observed. We explain this result by partial blocking of SERS-active sites by CDs and by formation of the CD inclusion complexes in the bulk solution instead of the AgNP surface. Therefore, the use of rinsing step of AgNP@CDs was proposed to improve SERS signal of ciprofloxacin. Compared to control AgNPs without the CD coating, rinsed AgNP@CDs have approximately 6 times larger intensity of SERS signal and better colloidal stability against increased ionic strength. Finally, SERS-based analysis protocol using AgNP@βCDs was developed and it can be applied for detection of ciprofloxacin residues in contaminated surface water at levels lower than minimum inhibitory concentration. The same protocol was also successfully tested for detection of some other fluoroquinolone antibiotics (enrofloxacin, norfloxacin, pefloxacin).
The work was supported by the Russian Science Foundation (project 21-73-00098)
Speaker
Natalia E. Markina
Saratov State University
Russia
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