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Pilot studies of complexes based on semiconductor quantum dots AIS / ZnS and aluminum phthalocyanine to increase the efficiency of phototheranostics.

Dmitry V. Yakovlev,1,3 Ekaterina P. Kolesova,2 Anna O. Orlova,2 Kirill I. Annas,2 Vladimir A. Oleinikov,1,2 1 Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Science, Moscow, Russia 2 ITMO University, St. Petersburg, Russia 3 Prokhorov General Physics Institute of the Russian Academy of Science, Moscow, Russia

Abstract

The methods of photodynamic therapy (PDT) and fluorescence diagnostics (PD) of malignant neoplasms have a number of advantages over other methods of diagnosis and treatment. One of the most important advantages of PD and PDT is the selective accumulation of a contrast agent, a photosensitizer (PS), in cancer cells. Also, PS molecules under the influence of laser light with a certain wavelength are capable of causing a cytotoxic effect in target cells due to the formation of singlet oxygen. Aluminum phthalocyanine is one of the most common fluorescent dyes approved for clinical use in oncological practice. However, it has a number of disadvantages, such as rapid removal from the pathological area. Colloidal quantum dots are a material devoid of such a drawback. When quantum dots are conjugated with PS, the elimination time increases by more than 10 times. This characteristic can also increase the effectiveness of therapy due to the absence of the need for constant PS injections before the PDT procedure. In addition, when using two-photon excitation for synthesized complexes, it is possible to increase the depth of probing of biological tissue due to the transition of exciting laser radiation to the near infrared region. In the experiment, complexes based on semiconductor quantum dots AIS / ZnS and PS of aluminum phthalocyanine were synthesized. The spectroscopic properties of the obtained conjugates were studied, and the efficiency of FRET from quantum dots to PS molecules was shown.


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Dmitry Yakovlev
1.Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Science, 2.Prokhorov General Physics Institute of the Russian Academy of Science
Russia

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