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Study of statistical properties of GB-speckles generated for the SARS–CoV-2 gene «S» for characterization of differences between Delta and other variants

Valentina A. Feodorova, 1 Sergey S. Zaitsev, 1 Onega V. Ulianova, 2 Alexander S. Ulyanov, 3 Sergey S. Ulyanov, 1,2 1 Federal Research Center for Virology and Microbiology, Branch in Saratov, Russia 2 Department of Medical Physics, Saratov State University, Saratov, Russia 3 Rocolabs, 27 West 24th Street Suite 704, New York, NY, 10010


As is known, Spike surface glycoprotein (protein S) is present in all coronaviruses, including the novel SARS-CoV-2 virus causing a global pandemic in 2019. In the present day, the relevant gene S (encoding protein S) undergoes the most mutations compared with other SARS-CoV-2 genes. In the beginning of 2021, the newer variant of the SARS-CoV-2, the Delta variant B.1.617, was discovered in India. It is distinguished by the presence of a double mutation of the Spike protein. In this study, the protein S sequences have been transformed into the sequence of numbers to generate the gene-based (GB-) speckles in order to identify the differences between the reference strain which was initially discovered in China, 2020 (GISAID: EPI_ISL_402124-S) and the new Delta strains which were recently found in either India (GISAID: EPI_ISL_254707; EPI_ISL_254707) or in the UK (GISAID:EPI_ISL_642476; EPI_ISL_255210). Differences in the relevant nucleotide sequences have been found and successfully characterized by means of virtual optical GB-speckles.


Sergey Zaitsev
Federal Research Center for Virology and Microbiology, Branch in Saratov, Russia


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