Flicker-Noise Spectroscopy Analysis of Magnetoencephalogram Signals in Diagnosis and Treatment of Photosensitive Epilepsy
Sergey A. Demin, 1 Valentin A. Yunusov, 1 Oleg Y. Panischev, 1 Serge F. Timashev, 2,3
1 Kazan Federal University, Kazan, Russia
2 Karpov Institute of Physical Chemistry, Moscow, Russia
3 National Research Nuclear University MEPhI (Moscow Engineering Physics Institute), Moscow, Russia
Abstract
Our study demonstrates the potential of flicker-noise spectroscopy (FNS) analysis of neuromagnetic brain responses (magnetoencephalogram, MEG) in possible diagnosis and estimating the effectiveness of treatment of photosensitive epilepsy. The tendency of the organism to restore the synchronization to its normal levels is considered the cornerstone of the analysis. A two-parameter FNS cross-correlation function is applied to show that the breakdown of frequency-phase synchronization in the MEG signals of the patient can be attributed to two distinct mechanisms: high-frequency resonances (50-100 Hz) at specific brain areas and changes in high-frequency stochastic components for other brain areas. Our analysis also reveals a certain disruption of regular behavior and occurrence of asymmetry in three-dimensional plots of the cross-correlation function for some healthy controls, suggesting that these individuals may be susceptible to photosensitive epilepsy. We believe that a similar cross-correlation analysis based on appropriate biomedical signals may be used to assess the effectiveness of medical treatment for other diseases and conditions.
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Sergey A. Demin
Kazan Federal University, Kazan
Russia
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