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Enhanced photodynamic action promoted by silver nanoparticles loaded on reduced graphene oxide sheets

Cynthia S.A. Caires,1, Luiz A.S. Farias,1, Luiz E. Gomes,1, Bruno P. Pinto,1,
Daniel A. Gonçalvesa,1, Luiz F. Zagonele,2 Valter A. Nascimento,1, Diego C.B. Alves,1, Ian Colbeck,3, Corinne Whitby,3, Heberton Wender,1, Anderson R.L. Caires,1 1 Laboratory of Optics and Photonics, Institute of Physics, Federal University of Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul 79070-900, Brazil 2 Gleb Wataghin” Institute of Physics, University of Campinas – UNICAMP, 13083-859 Campinas, São Paulo, Brazil 3 School of Life Sciences, University of Essex, Colchester CO4 3SQ, UK


The main motivation is to show that a combination of nanomaterials and light irradiation may be helpful to combat infectious diseases. It will be presented general motivations on: multi-drug microorganisms; antimicrobial photodynamic therapy (aPDT); nanoparticles in aPDT; photodynamic action of Silver nanoparticles (AgNPs); and enhanced photodynamic effect of AgNPs anchored on graphene oxide (GO). AgNPs anchored on GO have drawn considerable attention due to their capacity to efficiently inactivate bacteria though a multimode mechanism of action. Finally, it will be shown a recent published study, which demonstrates that coffee extract solution can be applied as a green reducing agent to prepare reduced GO sheets loaded with AgNPs. It also be demonstrated the enhanced aPDI effect of AgNPs when anchored on GO, against Staphylococcus aureus, under blue-light illumination.

Keywords: Antimicrobial photodynamic therapy; Silver nanoparticle; Graphene oxide; Blue light; Staphylococcus aureus.


Anderson Caires
Optics and Photonics Group, Institute of Physics, Federal University of Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul, Brazil


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