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Breast cancer cell damage induced by Zinc phthalocyanine Photosensitisers

Blassan George, Eric Aniogo and Heidi Abrahamse.

LASER RESEARCH CENTRE, FACULTY OF HEALTH SCIENCES, UNIVERSITY OF JOHANNESBURG, DOORNFONTIEN, JOHANNESBURG, SOUTH AFRICA

Abstract

Zinc phthalocyanine tetrasulfonic acid (ZnPcS4) mediated photodynamic killing of MCF-7 cells overexpressed with P-glycoprotein (P-gp) to investigate its response to cell death induction. The study provided evidence that ZnPcS4-PDT induced apoptotic induction on MCF-7/DOX cells. The apoptosis induced was not mitochondrial-dependent due to low cytochrome c release which supported the preferential localization of ZnPcS4 PS at the lysosome rather than mitochondria. The findings from this study suggests that PDT may act as a useful treatment modality for resistant cancer types.

Speaker

Blassan George
University of Johannesburg
South Africa

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