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Feasibility studies of an optimized LIBS system for biomedical applications

Keerthi K1, Sajan D George2, Ravikiran Ongole3, Santhosh Chidangil1 and Unnikrishnan V K1,
1 Centre of Excellence for Biophotonics, Department of Atomic and Molecular Physics, Manipal Academy of
Higher Education, Manipal-576104, India
2 Centre for Applied Nanosciences, Department of Atomic and Molecular Physics, Manipal Academy of Higher
Education, Manipal-576104, India
3. Department of Oral Medicine & Radiology, Manipal College of Dental Sciences, Mangalore, India

Abstract

Laser Induced Breakdown spectroscopy (LIBS) is a promising atomic emission spectroscopy technique for the characterization of material. It is a rapid analyzing tool which requires little or no sample preparation. Application of single shot LIBS are often unique and may have special advantageous; example less sample destruction. LIBS has been routinely applied in different types of biomedical species viz. calcified materials (such as teeth, bones, gallstones, etc.), and soft tissues (such as animal skin, muscle, nerve, etc.). One can identify healthy and carious tooth by monitoring the decrease or increase in concentrations of matrix elements such as Ca, Mg, P and non- matrix elements such as Na, Sr, Zn and C respectively. This information provides an easy methodology for the dentist to carry out real time monitoring and identification of dental caries if employed in vivo. Also, we have applied the developed LIBS technique to investigate the trace elements present in the body fluids (blood, serum, plasma) samples. The optically modified and developed system has high sensitivity with additional advantage of using very low excitation energy values. Results reveal that LIBS can be a potential tool to explore the elemental mapping in healthy to carious teeth and also for trace elemental detection in human blood samples with limited sample volume.

Speaker

KEERTHI K
Research Scholar
India

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