PHOTONIC AND ACOUSTIC TOOLS FOR THERANOSTICS

Abstract

Photonic and acoustic tools can be used for in vivo navigation, visualization, and activation of new types of multifunctional nanostructured particles. These particles will combine the ability to deploy drugs in a controllable manner with physical triggering, multimodal detection, and visualization as well as sensing of important biological markers. It was required to apply a new bottom-up method as layer by layer assembly and freezing induced loading and their combination. It can be allowed us to vary the volume fraction of components and their chemical composition led to the control of the physicochemical and mechanical properties of multifunctional carriers. Physical targeting of carriers was realized by the gradient of the magnetic field, optical tweezers approach. Acoustics has a good perspective for the same purpose. The carrier sensitivity to external influences as laser irradiation, ultrasound treatment can be changed by variation of volume fraction and chemical composition of inorganic nanoparticles and/or organic dyes in the carrier shells. The same approach is applied for drug delivery carriers imaging by MRI, OCT, and optoacoustic using inorganic nanoparticles and/or organic dyes as contrast or functional agents. The combination of photonic tools with multifunctional carriers has a good perspective for application in biomedicine for diagnostic and therapy.

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Speaker

Dmitry Gorin
Skolkovo Institute of Science and Technology
Russia

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