SYNERGISTIC THERAPEUTIC STRATEGIES FOR CANCER TREATMENT
Cancer is one of the major causes of death, with high incidence and mortality in the world, and is expected to continue increasing in the following 20 years. Monotherapy is difficult to achieve complete cure in malignant tumors, even causing drug resistance and severe side effects. Developing collaborative strategies of different treatments for both primary tumors clearance and distant metastases elimination is urgently required.Herein, in order to verify the therapeutic outcomes and support the synergistic hypothesis of combination between phototherapy and immunotherapy, we present one case of stage IV melanoma treated with laser irradiation and ipilimumab.All melanoma nodules on the head and neck were inhibited after phototherapy. However, there were no changes in pulmonary metastases. After the implementation of ipilimumab, all the pulmonary metastases were decreased and finally disappeared. We look forward to extending these observations to a greater number of patients to prove this hypothesis.
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