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In vivo Clinical Raman Spectroscopy: Non-invasive applications in Cancers

Advanced Centre for Treatment Research and Education in Cancer, Tata Memorial Centre, Kharghar, Navi Mumbai, India


Cancer is one of the leading causes of death and the high mortality rate, mainly due to late detection and recurrences, is ascribed to limitations of conventional diagnostic methodologies, which involve invasive procedures and are prone to subjective errors. Screening and early detection are thus main stay better for the overall management of cancer and to achieve better prognois. Hence it is vital to develop sensitive, objective and preferably non-invasive diagnostic methods. In this context, Raman spectroscopy, named after its discoverer Sir C.V. Raman, is better suited owing to attributes such as sensitivity to biochemical composition, objective, rapid, no external labeling/sample preparation, and most importantly in vivo/in situ on-line applications.
We have carried out extensive clinical trials of non-invasive (in vivo – on subjects) Raman spectroscopy applications in oral and cervical cancer. The present paper would provide an update of our explorations in theranostic applications.

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Dr. Murali Krishna C


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