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Single Visit photodynamic therapy protocol: Effectiveness and 2 years follow-up of 315 nodular basal cell carcinoma

Ana Gabriela Salvio,1, Mirian Denise Stringasci,2, Michelle Barreto Requena,2, Vanderlei Salvador Bagnato,2,3. 1 Skin Department of Amaral Carvalho Hospital, Jahu-SP, Brazil
2 Sao Carlos Institute of Physics, University of Sao Paulo (USP), Sao Carlos-SP, Brazil
3 Hagler Institute for Advanced Studies, Texas A&M University, College Station Texas, Texas, USA


Photodynamic therapy (PDT) is an important option for basal cell carcinoma (BCC) treatment. This study aimed to evaluate the effectiveness of a PDT single visit protocol in 2 years follow-up. 315 nodular BCC in 153 patients (48% male, 52% female, 63 years old in average) was selected from January 2016 to December 2019. The lesions were debulked and taken for histological evaluation. Then, a 20% methyl aminolevulinate hydrochloride cream (PDTPharma, Brazil) was applied and covered for 3 hours. The irradiation was performed for 20 min at 125 mW/cm² using the LINCE (MMOptics, Brazil). Then, the lesion received another amount of cream; was covered for 90 min and irradiated with the same parameters. 30 days after treatment, a 2mm punch biopsy was done to evaluate the treatment response. All patients were clinically evaluated every 6 months. Most of lesions were on head and neck (60%), followed by trunk (26%), upper limbs (13%) and lower limbs (1%). The 30th day biopsy showed 92.4% of complete response. The recurrence-free survival rates were estimated by Kaplan-Meier and the cumulative probability of recurrence-free survival of 95% (91.2-97.2%), 92.6% (87.8–95.5%), 90.7% (85.2-94.3%) and, 90.7% (85.2-94.3%) were observed at 12, 24, 36 and 48 months, respectively.


Mirian D. Stringasci
University of Sao Paulo


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