Protocol evaluation using a portable device in Photodynamic therapy of basal cell carcinoma to decrease the time in hospitals
Photodynamic therapy (PDT) is widely applied for non-melanoma skin cancer treatment. However, long stays in the hospital to perform the treatment have been disadvantageous to the patient and medical routine as well. A single visit PDT protocol performing the second irradiation at home has been developed by the group. The lesions were previously debulked, received the 20% methyl aminolevulinate hydrochloride cream (MAL, PDTPharma, Brazil) and were incubated for 3 hours. The first irradiation was performed in the hospital with 150 J/cm² in 20 min using the LINCE (MMOptics, Brazil). Then, the lesions received a thin cream layer and a portable irradiation prototype was fixed with a medical tape. Patients were instructed to turn on the irradiation device after 1.5 hours. In this pilot study, 3 different irradiation protocols using the prototype were tested: A) 168 J/cm² in 1h; B) 156 J/cm² in 2h, and, C) 312 J/cm² in 2h. In protocol A, 8 patients were treated and the complete response rate was 87.5%. Protocol B had 11 patients treated with a complete response rate of 63.6%. Finally, for protocol C, 16 patients were treated achieving 85.7% of complete response.
Michelle Barreto Requena
Sao Carlos Institute of Physics, University of Sao Paulo
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