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Protocol evaluation using a portable device in Photodynamic therapy of basal cell carcinoma to decrease the time in hospitals

Ana Gabriela Salvio,1, Michelle Barreto Requena, 2, Mirian Denise Stringasci, 2, Vanderlei Salvador Bagnato, 2,3. 1, Skin Department of Amaral Carvalho Hospital, Jahu-SP, Brazil, 2, Sao Carlos Institute of Physics, University of Sao Paulo (USP), Sao Carlos-SP, Brazil, 3 Hagler Institute for Advanced Studies, Texas A&M University, College Station Texas, Texas, USA

Abstract

Photodynamic therapy (PDT) is widely applied for non-melanoma skin cancer treatment. However, long stays in the hospital to perform the treatment have been disadvantageous to the patient and medical routine as well. A single visit PDT protocol performing the second irradiation at home has been developed by the group. The lesions were previously debulked, received the 20% methyl aminolevulinate hydrochloride cream (MAL, PDTPharma, Brazil) and were incubated for 3 hours. The first irradiation was performed in the hospital with 150 J/cm² in 20 min using the LINCE (MMOptics, Brazil). Then, the lesions received a thin cream layer and a portable irradiation prototype was fixed with a medical tape. Patients were instructed to turn on the irradiation device after 1.5 hours. In this pilot study, 3 different irradiation protocols using the prototype were tested: A) 168 J/cm² in 1h; B) 156 J/cm² in 2h, and, C) 312 J/cm² in 2h. In protocol A, 8 patients were treated and the complete response rate was 87.5%. Protocol B had 11 patients treated with a complete response rate of 63.6%. Finally, for protocol C, 16 patients were treated achieving 85.7% of complete response.

Speaker

Michelle Barreto Requena
Sao Carlos Institute of Physics, University of Sao Paulo
Brazil

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