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Gap-enhanced Raman tags for analytical and imaging applications

Boris Khlebtsov1, Andrey Burov1, Daniil Bratashov2, Nikolai Khlebtsov1,2

1 Institute of biochemistry and physiology of plants and microorganisms RAS, 410049 Saratov, Russia
2 Saratov State University, 410012 Saratov, Russia

Abstract

Gap-enhanced Raman tags (GERTs) are new emerging probes of the surface-enhanced Raman scattering (SERS) spectroscopy that have found promising analytical and bioimaging applications. Because of the internal localization of Raman reporter molecules, they are protected from unwanted external environments and particle aggregation and demonstrate superior SERS responses due to strongly enhanced electromagnetic fields in the gaps between metal core-shell structures. We discuss recent progress in the synthesis, design of optical properties, and biomedical applications of novel spherically symmetrical and anisotropic GERTs. Particular attention is paid to the use of nanoparticles as labels for immunoassays and for Raman bioimaging of cancer cells and tissues.

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Speaker

Boris Khlebtsov
IBPPM RAS
Russia

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