RAPID IN VIVO RAMAN SPECTROSCOPY FOR NON-INVASIVE SKIN CANCER DETECTION
Haishan Zeng, University of British Columbia and BC Cancer Research Centre, Vancouver, BC, Canada
Abstract
Raman spectroscopy is a powerful non-invasive optical technique for biochemical composition analysis. However, the inherent weak signal of Raman scattering makes it a great challenge for in vivo tissue analysis. We have developed a proprietary technology that meets the challenge and implemented in vivo diagnostic application for skin cancer detection. The clinical Raman system employs a fiber optic probe for excitation laser delivery and Raman signal collection and a unique way to correct spectrograph image distortion, realized a >16 S/N improvement. The system is capable of acquiring a spectrum from skin tissue in vivo in about 1 second, facilitating practical clinical applications. We have collected Raman spectra from more than 1,000 skin lesions including skin cancers: melanoma, squamous cell carcinoma, and basal cell carcinoma. Diagnostic algorithms based on PCA-GDA/PLS-DA were developed that could calculate the posterior probability of a lesion being skin cancer within 0.5 seconds. Thus rapid automatic diagnosis is completed within less than 2 seconds. The system has been commercialized (Verisante AuraTM/Vita AuraTM) and received regulatory approval from Health Canada and Europe. The system architecture and clinical results will be presented.
Speaker
Haishan Zeng
University of British Columbia
Canada
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