3D bioprinted fibrin-gelatin-based structures preserve the functionality of MSC spheroids
Polina Y. Bikmulina, 1, Nastasia V. Kosheleva, 1,2,3,4, Anastasia I. Shpichka, 1,2, Yury M. Efremov, 1,2, Anastasia S. Kuryanova, 1,5, Georgy K. Vladimirov, 1, Kseniia N. Bardakova, 2,6, Peter S. Timashev, 1,2,5,7
1 World-Class Research Center “Digital Biodesign and Personalized Healthcare,” Sechenov University, Moscow, Russia
2 Institute for Regenerative Medicine, Sechenov University, Moscow, Russia
3 Laboratory of Clinical Smart Nanotechnology, Sechenov University, Moscow, Russia
4 FSBSI Institute of General Pathology and Pathophysiology, Moscow, Russia
5 Department of Polymers and Composites, N.N.Semenov Federal Research Center for Chemical Physics, Russain Academy of Sciences, Moscow, Russia
6 Institute of Photon Technologies, Research Center Crystallography and Photonics RAS, Moscow, Russia
7 Chemistry Department, Lomonosov Moscow State University, Moscow, Russia
Abstract
Novel stable and biocompatible biomaterials for 3D bioprinting are of high interest. Here, bioink based on modified natural polymers were characterized and used for the 3D printing of MSC spheroids. Obtained structures were viable and stable. 3D printed hydrogels provided cell proliferation, migration and differentiation.
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Polina Bikmulina
World-Class Research Center “Digital Biodesign and Personalized Healthcare,” Sechenov University, Moscow, Russia
Russia
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