Control of the ice ball formation during tissue cryosurgery using sapphire shaped crystals
Zotov A.K. 1, Dolganova I.N. 1,2, Shikunova I.A. 1, Safonova L.P. 4,
and Kurlov V.N. 1
1 Institute of Solid State Physics of the Russian Academy of Sciences,
2 Sechenov First Moscow State Medical University
3 Prokhorov General Physics Institute of the Russian Academy of Sciences
4 Bauman Moscow State Technical Universitys
Abstract
Cryosurgery is applied in medicine for rapid freezing and destroying or renewing of pathological tissues via cryodestruction. Advantages of this method are its relative painlessness, hemostatic effect, minimal damage to healthy tissues while providing access to hard-to-reach areas, including inoperable tumors, and shorter patient rehabilitation. However, process of cryodestruction may cause risks of damage of surrounding healthy tissues, as well as incomplete cell death. To increase the effectiveness of this method, it is important to control the tissue freezing depth in each specific case .
We propose using optical methods and, in particular, diffuse reflectance spectroscopy and optical coherence tomography for non-invasive control of tissue freezing. To implement these methods, we use sapphire shaped crystals for making cryoapplicators. Sapphire is characterized by high transparency in a wide spectral range, chemical resistance and high thermal conductivity at cryogenic temperatures; thus, it provides a suitable platform for cryosurgery. We develop the applicators and experimentally confirm the possibility to monitoring of the ice ball formation in tissues during their freezing.
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Speaker
Arsen Zotov
Institute of Solid State Physics of the Russian Academy of Sciences
Russia
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