Electrospectral systems based on surface-enhanced Raman spectroscopy for bioanalysis: a literature overview
Electrochemical analysis and spectroscopic analysis are two “classical” and widely used approaches in bioanalysis while their combination is not so wide spread at the moment. Additionally, there is a lack of systematic information regarding to the topic. Therefore, in this report we summarize and analyze the achievements in the field of bioanalysis using the surface-enhanced Raman spectroscopy (SERS) coupled with electrochemical techniques (EC-SERS). The overview includes analysis of (i) diverse constructions of registration cells, (ii) fabrication and composition of SERS-active electrodes, and (iii) analytical performance and figures of merit of the published protocols. Finally, the advantages and limitations of EC-SERS are thoroughly analyzed and discussed and the perspectives of this approach for biomedical analysis and therapeutic drug monitoring are highlighted.
The work was supported by Russian Science Foundation (project 18-13-00081).
Alexandra I. Danchuk
Saratov State University
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