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Visualization of detonation nanodiamonds using coherent anti-Stokes light scattering spectroscopy

K.A. Laptinsky1,2, S.A. Burikov1,2, O.A. Shenderova3, T.A. Dolenko1,2

1 Skobeltsyn Institute of Nuclear Physics, Lomonosov Moscow State University, Russia
2 Faculty of Physics, Lomonosov Moscow State University, Russia
3 Adamas Nanotechnologies, Inc, Raleigh, NC, USA

Abstract

Nanotechnology is actively developing in many fields, especially in biomedicine, due to the increasing accumulation of information about the chemical and biological processes occurring at the cellular and molecular levels of the organization of life. One of the ways to use nanotechnology in biomedicine is to create theranostic particles capable of simultaneously performing several functions, as like, diagnostics and therapy of diseases. Nowadays, various particles are widely studied, which have the potential to be used as theranostic agents: organic dyes, complexes based on noble metals, quantum dots, etc. There are a number of general requirements imposed on such nanocomplexes: they must be small enough to penetrate cells, non-toxic, and biocompatible. Carbon nanoparticles, in particular, nanodiamonds, are convincingly possessed of such properties.
In this work, detonation nanodiamonds were visualized in the volume of biological tissue by the method of coherent anti-Stokes light scattering (CARS) spectroscopy. To obtain the CARS signal, the system consisting of a pulsed Nd:YAG laser and a parametric light generator, which allows the radiation to be tuned in the range of 530-710 nm was used. CARS signals of carbon nanoparticles (carbon dots and detonation nanodiamonds) were obtained in aqueous suspensions and in the volume of biological tissue (egg white). The analysis of the obtained spectra made it possible to conclude the fundamental possibility of using CARS spectroscopy for visualizing nanoparticles in the tissue volume.
This work was supported by the Russian Science Foundation (project No. 20-72-00144).


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Laptinskiy Kirill
Skobeltsyn Institute of Nuclear Physics, Lomonosov Moscow State University, Russia
Russia

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