NMR SPECTROSCOPY IN STRUCTURE DETERMINATION OF A NUMBER OF POLYSUBSTITUTED PYRIDINES AND THIAZOLOPYRIMIDINES
Using one-dimensional and two-dimensional NMR methods (1H, 13C, HMBC, COSY, HSQC) the structure of compounds of a variety of hydroxythiazolopyrimidincarboxylates, its dehydrated forms and chromenopyridinecarbonitriles was established and isomerization transformations were studied. These compounds were obtained in stages or by three-component condensation of heterocyclic amines (1,3-thiazole-2-amine, 2-aminopyridine), substituted aromatic aldehydes and active methylene compounds (ethyl acetoacetate, malononitrile).
Saratov State University
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