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NMR SPECTROSCOPY IN STRUCTURE DETERMINATION OF A NUMBER OF POLYSUBSTITUTED PYRIDINES AND THIAZOLOPYRIMIDINES

Vasilkova N.O., Saratov State University, Russia
Vasil’yeva E.S., Saratov State University, Russia
Meshcheryakova A.A., Saratov State University, Russia
Sorokin V.V., Saratov State University, Russia
Kriven’ko A.P., Saratov State University, Russia

Abstract

Using one-dimensional and two-dimensional NMR methods (1H, 13C, HMBC, COSY, HSQC) the structure of compounds of a variety of hydroxythiazolopyrimidincarboxylates, its dehydrated forms and chromenopyridinecarbonitriles was established and isomerization transformations were studied. These compounds were obtained in stages or by three-component condensation of heterocyclic amines (1,3-thiazole-2-amine, 2-aminopyridine), substituted aromatic aldehydes and active methylene compounds (ethyl acetoacetate, malononitrile).

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Meshcheryakova A.A.
Saratov State University
Russia

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