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Effect of ex vivo skin drying on collimated transmittance spectra kinetics

Sergey Zaytsev1,2, Alexey N. Bashkatov1,3, Walter Blondel2, Marine Amouroux2, Valery V. Tuchin1,3,4, Elina A. Genina1,3.
1 Saratov National Research State University;
2 Université de Lorraine
3 Tomsk State University;
4 Institute of Precision Mechanics and Control, RAS, Saratov, Russia

Abstract

Considerable attention in medicine and science is paid to the skin. Non-invasive optical methods allowing for acquisition of quantitative and qualitative information about biological tissue through the skin ex vivo and in vivo, thus improving efficiency of the diagnostic performance. However, due to its strong scattering properties skin is the main barrier that can weaken possible depth and contrast of biological tissue analysis by optical techniques, that will reduce the promising positive effect of the latter.
As a result of many years of research, it was found that the dehydration is one of the main mechanisms leading to reduce in skin thickness and backscattering, that may lead to the better photons propagation within the biological tissue, raising the contrast and depth resolution of applied optical techniques. The goal of the study was to investigate the effect of ex vivo skin drying on the acquired collimated transmittance spectra.
In this work we analyzed the kinetics of collimated transmittance spectra of ex vivo drying rat skin, recorded in UV-VIS-NIR optical range with spectrometer. During the experimental protocol, we measured the thickness of each skin sample after each measurement. We also measured initial and final weight of each sample to estimate the water loss due to evaporation.

Speaker

Zaytsev Sergey
Université de Lorraine
France

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