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Quantitative benign and malignant human breast tumors assessment using cross-polarization optical coherence tomography

Ekaterina V. Gubarkova, Alexander A. Moiseev, Elena B. Kiseleva, Dmitry A. Vorontsov, Sergey S. Kuznetsov, Alexey Y. Vorontsov, Grigory V. Gelikonov, Elena V. Zagaynova, Marina A. Sirotkina and Natalia D. Gladkova


Optical coherence tomography (OCT) is a promising method for detecting breast cancer margins during tumor resection. This study focused on differentiating benign and malignant lesions in human breast tissues using cross-polarization OCT (CP OCT). The study was performed on fresh ex vivo human breast tissues from 40 patients with different subtypes of breast cancer. Different tissue types that surgeons should clearly distinguish during surgery, such as the adipose tissue, normal stroma, tumor stroma and agglomerates of tumor cells, were separately analyzed. Based on volumetric CP OCT data, tumorous and normal breast tissue were differentiated using three optical coefficients - attenuation in the co- channel, attenuation in the cross- channel and the interchannel attenuation difference. The attenuation in the cross- channel of the tumor were significantly different between benign and malignant masses. The attenuation in the cross- channel and the interchannel attenuation difference provided greater contrast for the visualization of the different breast cancer structures compared to the attenuation coefficient in the co- channel. The presence of particular morphological patterns, such as fibrosis or hyalinosis of the tumor stroma, can lead to dramatic changes in coefficient values and create some difficulties in differentiating between tissues. The clinical use of CP OCT could assist the breast surgeon in detecting positive resection margins during breast surgery.


Ekaterina V. Gubarkova
Privolzhsky Research Medical University


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