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Tissue optical clearing in the ultraviolet for clinical use in dentistry to optimize the treatment of chronic recurrent aphthous stomatitis

A.A. Selifonov 1,2, V.V. Tuchin1,3,4, 5

1 Saratov State University, Saratov 410012, Russian Federation
2 Children's Polyclinic No.3 of the Children's Infectious Diseases Clinical Hospital No.5, Saratov 410031, Russian Federation
3 National Research Tomsk State University, Tomsk 634050, Russian Federation
4 Institute of Precision Mechanics and Control of the Russian Academy of Sciences, Saratov 410028, Russian Federation
5 А.N. Bach Institute of Biochemistry, Research Center of Biotechnology of the Russian Academy of Sciences, Moscow 119071, Russian Federation

Abstract

The immersion optical clearing (OC) treatment with a highly concentrated glycerol has induced three new tissue windows in the UV spectral range of gingival tissues – from 200 to 250 nm, from 250 to 300 nm and from 300 to 400 nm. By combining the immersion OC technique in human tissues with UV-spectroscopy, it was possible to verify and study the major OC mechanisms – tissue dehydration and reversible collagen dissociation, and that the OC efficiency is higher in the deep-UV than in the visible-NIR range. Since all biological tissues present high scattering in the UV range, the presented technology, which basically reduces the strong light scattering in the UV range, has a broad application area in medicine. The effectiveness of the developed technology combining UV phototherapy and OC in application to treatment of aphthous recurrent stomatitis in children was demonstrated.

Speaker

Alexey Selifonov
Saratov State University
Russian Federation

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