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Determination of the binary diffusion coefficient of an iodine-glycerol preparation (Lugol) in the dentin of a human tooth

A.A. Selifonov 1,2, V.V. Tuchin1,3,4,5

1 Saratov State University, Saratov 410012, Russian Federation
2 Saratov State Medical University, Saratov 410012, Russian Federation
3 National Research Tomsk State University, Tomsk 634050, Russian Federation
4 Institute of Precision Mechanics and Control of the Russian Academy of Sciences,
Saratov 410028, Russian Federation
5 А.N. Bach Institute of Biochemistry, Research Center of Biotechnology of the Russian Academy of Sciences, Moscow 119071, Russian Federation

Abstract

Lugol as an antiseptic dye based on iodine and glycerol is widely used in clinical dentistry to identify areas of tooth demineralization and to detect initial caries. In this work, the kinetic parameters of Lugol (aqueous solution of potassium iodide (0.02 w/w) and glycerol (0.94 w/w)) diffusion in the dentin of a human tooth are determined. A modified Fick's second law, free diffusion model, and diffuse reflectance spectroscopy were used to determine the effective Lugol diffusion coefficient (binary diffusion coefficients of tissue water and iodine/glycerol complex) in the dentin of a human tooth. The quantitative parameters of Lugol's penetration into the dentin of a human tooth and a change in its optical properties should be taken into account when drawing up clinical protocols for the treatment of dental diseases using phototherapy, physiotherapy, photodynamic therapy, laser treatment, etc.

Speaker

Alexey Selifonov
Saratov State University
Russian Federation

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