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MRI contrast control of submicron carriers loaded with magnetite nanoparticles

Anastasiia A. Kozlova 1, Sergey V. German 2,3, Vsevolod S. Atkin 1, Victor V. Zyev 4, Maxwell Astle 5, Daniil N. Bratashov 1, Yulia I. Svenskaya 1 and Dmitry A. Gorin 3

1 Saratov State University, Saratov, Russia
2 Institute of Spectroscopy of the Russian Academy of Sciences (ISAN), Troitsk, Russia
3 Skolkovo Institute of Science and Technology, Skolkovo Innovation Center, Moscow, Russia
4 Saratov State Medical University, Saratov, Russia
5 School of Chemistry, University of Nottingham, University Park, NG7 2RD, UK

Abstract

Magnetic contrast agents are widely used in magnetic resonance imaging in order to significantly change the signals from the regions of interest in comparison with the surrounding tissue. Despite a high variety of single-mode T1 or T2 contrast agents, there is a need for dual-mode contrast from the one agent.
In this study, we developed the drug delivery systems with controllable structure-dependent MRI contrast, based on dual-mode contrast Fe3O4 nanoparticles. We showed the ability to control magnetic resonance contrast by changing not only the number of magnetite nanoparticles in one carrier or the concentration of magnetite in the suspension but also the structure of the core-shell itself. These carriers are able not only to change the contrast after their degradation but also to have various T1 and T2 contrast properties depending on the amount and localization of iron oxide nanoparticles. The obtained data open up the prospects for dual-mode T1/T2 magnetic contrast formation as well as provides the basis for future investigations in this direction.

Acknowledgments.
This research was funded by Russian Science Foundation, grant number 18-19-00354.


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Anastasiia Kozlova
Saratov State University
Russia

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