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Preferential accumulation of carriers in the target organ after delivery via the renal artery

Ekaterina S. Prikhozhdenko (Saratov State University, 83 Astrakhanskaya str., Saratov 410012, Russia)

Olga I. Gusliakova (Saratov State University, 83 Astrakhanskaya str., Saratov 410012, Russia)

Oksana A. Mayorova (Saratov State University, 83 Astrakhanskaya str., Saratov 410012, Russia)

Natalia A. Shushunova (Saratov State University, 83 Astrakhanskaya str., Saratov 410012, Russia)

Arkady S. Abdurashitov (Skolkovo Institute of Science and Technology, Skolkovo Innovation Center, Building 3, Moscow, 143026, Russia)

Dmitry A. Gorin (Skolkovo Institute of Science and Technology, Skolkovo Innovation Center, Building 3, Moscow, 143026, Russia)

Gleb B. Sukhorukov (Skolkovo Institute of Science and Technology, Skolkovo Innovation Center, Building 3, Moscow, 143026, Russia; School of Engineering and Materials Science, Queen Mary University of London, Mile End, Eng, 215, London E1 4NS, United Kingdom)

Olga A. Sindeeva (Skolkovo Institute of Science and Technology, Skolkovo Innovation Center, Building 3, Moscow, 143026, Russia; Saratov State University, 83 Astrakhanskaya str., Saratov 410012, Russia)

Abstract

Here, we report the combination of advanced technologies in the field of clinical approaches and materials science. The injection through the renal artery brings a preferential accumulation of cargo to the target kidney. The slow release of the model substance is provided by layer-by-layer encapsulation inside the biodegradable polymer shell.

The developed methodology for addressing the model fluorescent substance to the target kidney made it possible: (i) significantly increase (by 9 times) the efficiency of the fluorescent agent delivery in comparison with the traditional method of intravenous administration; (ii) increase the duration of the presence of the dye in the target organ. Overall delivery efficacy is approximately 20% of the injected dosage.

A detailed analysis of the fluorescent capsules localization in the kidney tissues revealed that carriers accumulate mainly in the kidney glomerulus, but are almost completely washed out from there during the first day after injection. In this case, the cargo released from the microcapsules remained in the kidney for two days after the administration of the carriers.

This work was supported by Russian Science Foundation (project no. 19-75-10043).


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Ekaterina Prikhozhdenko
Saratov State University
Russian Federation

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