In vivo MRI imaging of submicron polyelectrolyte capsules loaded with magnetite nanoparticles under magnetic navigation
The search for novel drug delivery technologies is driven by the observation that many therapeutic agents failed due to their limited ability to reach the target tissue and their poor selectivity against diseased cells. In addition, drug delivery systems can solve problems associated with drug instability in the biological environment as well as issues related to the modulation of drug clearance and metabolism. Improved delivery systems are most in need for the treatment of cancer, respiratory and central nervous system diseases, and cardiovascular disorders. An important improvement in designing new nanocarriers is to put the proper attention to their biodegradability, because of the toxicity concerns that often accompany the use of nanoparticles.
The research is aimed at searching for novel biodegradable drug delivery systems for theranostics. MRI contrast submicron Layer-by-layer (LbL) self-assembled polyelectrolyte capsules containing magnetite nanoparticles were designed, prepared and characterized in vitro and in vivo. The system showed a good T2 contrast both under its uptake by macrophages in vitro and after the injection in a murine breast cancer model in vivo. Magnetic targeting was used to improve the accumulation of such capsules in tumor.
The study was supported by RSF (project No 19-73-10123).
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Saratov State University
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