Mesoporous CaCO3 vaterite microparticles with polyelectrolyte coatings for transdermal drug delivery
A novel particulate system for transdermal drug delivery based on the mesoporous CaCO3 vaterite submicron particles was developed. The potential efficiency of the developed system was demonstrated with the antifungal drug "Griseofulvin" (GF) by the topical application on white rats in vivo. The loading efficiency of GF in CaCO3 microcarriers was 22 % w/w. Efficient transportation of the proposed particulate system into the skin was demonstrated in vivo in rats. The carriers were successfully accumulated inside the hair follicles. The study of GF urinary excretion profiles in course of 2 weeks was monitored in vivo on rats. In order to prolong the degradation of CaCO3 carriers and the GF release inside the skin, their surface was modified with biocompatible polyelectrolytes using layer-by-layer technique. It was demonstrated, that the formation of polyelectrolyte shell on the carrier surface provided the prolongation of drug release kinetics. The developed drug delivery system, based on vaterite submicron carriers, for topical treatment of dermal diseases, demonstrates the opportunities for improving efficiency and safety of therapy of dermatophyte infections.
This study was supported by Russian Science Foundation (project № 17-73-20172).
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Saratov State University, 410012, 83 Astrakhanskaya Street, Saratov, Russia
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