Particulate System for Efficient Non-Invasive Transdermal Drug Delivery
Irrational use of antimicrobial agents, including their overuse, polypharmacy, as well as the assignment of injections in cases where oral or external forms of the drug are suitable for treatment, leads to the development of resistance of microorganisms, which is accompanied by an increase in the incidence rate, as well as a constant increase in health care expenses. The development of approaches that ensure the effective use of existing antimicrobial agents is an important task. We propose an approach which is aimed on increasing the therapeutic efficacy of antifungal drugs in terms of the treatment of dermatomycosis, due to an increase in their local concentration and the probability of accumulation in the lesion area, which ensures a reduction in the dose of the drug used together with reducing side effects associated with its administration. To achieve these goals, a non-invasive introduction method was developed for the effective delivery of antifungal agents to and through the skin appendages (hair follicles and funnels, ducts of the sebaceous and sweat glands) directly to the areas of pathological processes localization using submicron porous calcium carbonate particles in the modification of vaterite, which enable control over release in the lesion area. In addition, the developed system for drug delivery to the skin appendages opens up a venue for creating depot systems for systemic therapy, which is able to reduce the drug load on the body and prolong the therapeutic effect.
The study was supported by RSF (project No 17-73-20172).
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Saratov State University
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