Prospective strategies for enhanced intra- and transdermal delivery of antifungal drugs
Ekaterina V. Lengert, Saratov State University, Saratov 410012, Russia
Ekaterina E. Talnikova, Saratov State Medical University, Saratov 410000, Russia
Roman A. Verkhovskii, Saratov State University, Saratov 410012, Russia
Mariia S. Saveleva, Saratov State University, Saratov 410012, Russia
Valery V. Tuchin, Saratov State University, Saratov 410012, Russia; Tomsk State University, Tomsk 634050, Russia; Institute of Precision Mechanics and Control of the Russian Academy of Sciences, Saratov 410028, Russia
Yulia I. Svenskaya Saratov State University, Saratov 410012, Russia
Abstract
The present work is focused on novel nano- and micro-based formulations served to improve antimycotics penetration through the skin for the treatment of superficial fungal infections. Encapsulation of antifungal drugs into nano- and micron-sized carriers allows for further enhancement of mycosis treatment, particularly therapeutic activity, and prolonged effect while avoiding high toxicity.
Enhanced transdermal drug delivery opens up the prospective for effective treatment of superficial fungal infections as provides the accumulation of antimycotics in the targeted skin sites.
This study was supported by RSF (project № 17-73-20172).
Speaker
Lengert Ekaterina Vladimirovna
Saratov State University
Russia
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