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Non-invasive assessment of fluid retention in tissues by direct measurements of capillary parameters using optical microscopy

D. A. Davydov 1, B. P. Yakimov 1, G.S. Budylin 2, V.V. Fadeev 1, Y.I. Gurfinkel 3, E.A. Shirshin 1,2
1 Department of Physics of M.V. Lomonosov Moscow State University Leninskye Gory 1-62, 119991 Moscow, Russia
2 Institute of spectroscopy of the Russian Academy of Science Fizicheskaya Str., 5, 108840, Troitsk, Moscow, Russia
3 M.V. Lomonosov Moscow State University Clinics Lomonosovsky prospect 27-10, 119991 Moscow, Russia

Abstract

A quantitative assessment of edema syndrome that can occur in various diseases, such as chronic heart failure or renal impairment is an urgent and yet unsolved problem. Fluid retention in tissues occurs as a result of an imbalance in transcapillary system, through which water and nutrients are exchanged between the circulatory blood system and other tissues. The videocapillaroscopy is the gold standard technique to study nailfold capillaries. In this work, we show that the size of the perivascular zone and the apical diameter of the capillary loop – the capillary section, which separates venous and arterial sections – can change upon changes in fluid flow in tissues and that both these parameters are suitable for assessing the fluid retention in the tissues. We demonstrate the diagnostic value of these parameters both in the model experiments like venous and arterial occlusion, and in real clinical case of patients undergoing treatment with diuretics. We believe these parameters will find its diagnostic application in a clinical setting.

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Davydov Denis
Department of Physics of M.V. Lomonosov Moscow State University Leninskye Gory 1-62, 119991 Moscow
Russia

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