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Photostimulation of permeability of blood-brain barrier for beta-amyloid

Maria Klimova, Saratov State University, Russia; Aysel Mamedova, Saratov State University, Russia; Ilana Agranovich, Saratov State University, Russia; Inna Blokhina, Saratov State University, Russia; Tatiana Antonova, Saratov State University, Russia; Andrey Terskov, Saratov State University, Russia; Alexander Shirokov, Saratov State University, Russia; Nikita Navolkin, Saratov State University, Russia; Oxana Semyachkina-Glushkovskaya, Saratov State University, Russia

Abstract

Alzheimer's disease (AD) is an incurable pathology associated with progressive decline in memory and cognition. The phototherapy might be a new promising and alternative strategy for the effective treatment of AD that has been actively discussed over two decades. However, the mechanisms of therapeutic photostimulation (PS) effects on subjects with AD remain poorly understood. Here we demonstrate that transcranial PS 9 J/cm2 attenuates the memory and neurological deficit in mice with AD via activation of lymphatic clearance of Aβ from the brain. We show that the PS-mediated opening of the blood-brain barrier via the PS-decrease of the transendothelial resistance and the expression of tight junction proteins might be the crucial mechanism underlying therapeutic effects of PS in mice with AD. These pioneering data opens new strategies in the development of non-pharmacological methods for therapy of AD and contributes to a better understanding of the PS effects on the central nervous system.

Speaker

Klimova Maria (mari-1997@mail.ru)
Saratov State University
Russia

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