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Direct measurements of rat intracranial pressure

V.B. Ageev, Department of optics and biophotonics, Saratov State University, 83 Astrakhanskaya, 410012 Saratov, Russia
I.A. Blokhina, Department of Human and Animal Physiology, Saratov State University, 83 Astrakhanskaya, 410012 Saratov, Russia
I.V. Fedosov, Department of optics and biophotonics, Saratov State University, 83 Astrakhanskaya, 410012 Saratov, Russia
O.V. Semyachkina-Glushkovskaya, Department of Human and Animal Physiology, Saratov State University, 83 Astrakhanskaya, 410012 Saratov, Russia

Abstract

Accurate and reproducible measurements of intracranial pressure during sleep are а key to the understanding of brain clearing through the circulation of cerebrospinal fluid. Existing methods are based on the use of a flexible catheter or fiber light guide sensor that makes sealing difficult and reduces measurement accuracy. We have proposed a method that uses two integral solid state sensors, one of which measures atmospheric pressure, and the other directly closes the opening in the animal's skull to measure the cerebrospinal fluid pressure in the subarachnoid space. The paper presents the results of measuring the intracranial pressure in a rat during sleep and wakefulness; it was found that intracranial pressure increases upon awakening, and also changes when the head and trunk are raised, when the animal turns over on its back. The proposed method provides high sensitivity; minimizes measurement errors; and practically eliminates trauma to the brain during the installation and operation of the sensor; our ICP data are in good numerical agreement with the data of other authors.

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Ageev Vasily
Direct measurements of rat intracranial pressure
Saratow

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