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Water migration in skin after optical clearing

Anton Yu. Sdobnov,1 Johannes Schleusener,2 Jürgen Lademann,2 Valery V. Tuchin,3,4,5,6 Maxim E. Darvin2

1Faculty of Information Technology and Electrical Engineering, University of Oulu, Oulu 90570, Finland
2Center of Experimental and Applied Cutaneous Physiology, Department of Dermatology,
Venerology and Allergology, Charité – Universitätsmedizin Berlin, Corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Charitéplatz 1, 10117
Berlin, Germany
3Research-Educational Institute of Optics and Biophotonics, Saratov State University, 83
Astrakhanskaya st., Saratov 410012, Russian Federation
4Laboratory of Laser Diagnostics of Technical and Living Systems, Institute of Precision
Mechanics and Control of the RAS, Saratov 410028, Russian Federation
5Laboratory of Molecular Imaging, Bach Institute of Biochemistry, Research Center of
Biotechnology of the RAS, Moscow 119071, Russian Federation
6Interdisciplinary Laboratory of Biophotonics, Tomsk State University, Tomsk 634050, Russian Federation


The application of optical clearing agents on skin allows for controlling the optical properties of skin and, thus, for enhancement of optical probing depth. However, optical clearing agents can affect skin hydration, which is an important parameter critical for maintaining healthy skin conditions. This presentation presents results of investigation of optical clearing influence on the water content in the skin using confocal Raman spectroscopy.


Anton Sdobnov
University of Oulu


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