Determination of changes in skin tissue during the development of malignant neoplasms by Monte Carlo simulation and Multivariate Curve Resolution – Alternating Least Squares
The paper discusses different approaches to determination of changes in the skin component concentrations during the malignant neoplasm development. Monte Carlo simulation of Raman light scattering and multivariate curve resolution–alternating least squares (MCR-ALS) are analyzed. Normal skin, malignant melanoma and basal cell carcinoma are studied. Raman spectra of skin have been simulated using an additive simulation approach. The findings suggest that these approaches could be useful for estimation changes in the concentration of skin components with the development of malignant neoplasms.
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