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Dose-dependent dynamics of tumor growth under the influence of Chlamydia psittaci AMK-16 specific ornithosis antigen

Anna Lyapina, Federal Research Center for Virology and Microbiology, Branch in Saratov, Russia
Maxim Lavrukhin, Federal Research Center for Virology and Microbiology, Branch in Saratov, Russia
Larisa Padilo, Federal Research Center for Virology and Microbiology, Branch in Saratov, Russia
Maria Khizhnyakova, Federal Research Center for Virology and Microbiology, Branch in Saratov, Russia
Nadegda Filonova, Federal Research Center for Virology and Microbiology, Branch in Saratov, Russia
Onega Ulianova, Saratov State University, Russia
Galina Maslyakova, Saratov State Medical University n.a. V.I. Razumovsky, Russia
Alla Bucharskaya, Saratov State Medical University n.a. V.I. Razumovsky, Russia
Nikita Navolokin, Saratov State Medical University n.a. V.I. Razumovsky, Russia
Sergey Dobdin, Saratov State University, Russia
Anatoly Skripal, Saratov State University, Russia
Vitaly Evstifeev, Federal Center for Toxicological, Radiation and Biological Safety, Kazan, Republic of Tatarstan, Russia
Sergey Ulyanov, Federal Research Center for Virology and Microbiology, Branch in Saratov, Russia; Saratov State University, Russia
Valentina Feodorova, Federal Research Center for Virology and Microbiology, Branch in Saratov, Russia

Abstract

Our previous study has revealed that specific ornithosis antigens extracted from Сhlamydia psittaci (CP) could possess some modulatory activity on the growth of malignant solid tumors in Wistar rats. Here, in the same model we studied dose-dependent dynamics of tumor growth under the influence of CP antigen derived from CP AMK-16 strain, in doses ranged from 0.025 mg/kg to 1.25 mg/kg given as a single subcutaneous injection. Velocity of tumor growth has been estimated by s-LASCA technique. We showed that only the highest dose of CP antigen had an inhibitory effect on tumor development in comparison with the control untreated group, while other doses, conversely, stimulated tumor to progress. However, at the same time the group treated with 1.25 mg/kg of СP antigen demonstrated the highest tumor growth rate with the maximum rate at the first week after injection of CP antigen. In conclusion, our study showed the complexity of the dynamics of tumor growth under the influence of CP specific ornithosis antigen.

Speaker

Anna Lyapina
Federal Research Center for Virology and Microbiology, Branch in Saratov
Russia

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