Dose-dependent dynamics of tumor growth under the influence of Chlamydia psittaci AMK-16 specific ornithosis antigen
Our previous study has revealed that specific ornithosis antigens extracted from Сhlamydia psittaci (CP) could possess some modulatory activity on the growth of malignant solid tumors in Wistar rats. Here, in the same model we studied dose-dependent dynamics of tumor growth under the influence of CP antigen derived from CP AMK-16 strain, in doses ranged from 0.025 mg/kg to 1.25 mg/kg given as a single subcutaneous injection. Velocity of tumor growth has been estimated by s-LASCA technique. We showed that only the highest dose of CP antigen had an inhibitory effect on tumor development in comparison with the control untreated group, while other doses, conversely, stimulated tumor to progress. However, at the same time the group treated with 1.25 mg/kg of СP antigen demonstrated the highest tumor growth rate with the maximum rate at the first week after injection of CP antigen. In conclusion, our study showed the complexity of the dynamics of tumor growth under the influence of CP specific ornithosis antigen.
Federal Research Center for Virology and Microbiology, Branch in Saratov
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