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Advances in physicochemical methods for early diagnosis of diseases based on the analysis of human exhaled breath

A.N. Morozov1, I.L. Fufurin1 and O.A. Nebritova1
1Bauman Moscow State Technical University, Moscow, Russia

Abstract

Exhaled breath analysis containing more than a thousand volatile organic compounds (VOC) biomarkers that can be capable of non-invasive diagnosis of diseases at the point of care. Despite the fact that the relationship of the VOCs with pathologies has been well studied, the diagnosis of exhaled breath remains analytically and practically a difficult task. This is related to the concentration level in ppb and sub-ppb. In addition to the already well-known “gold standard technique” in the analysis of low concentrations, such as gas chromatography and mass spectrometry, more modern methods using a quantum cascade laser (QCL) are of increasing interest. The Quantum Cascade Laser Absorption Spectroscopy (QCLAS) method is a relatively new and perspective method that offers an advantage in the creation of compact trace quantity sensors with high selectivity and sensitivity. This article highlights trends in the current state of advances in the development of methods and tools, as well as possible prospects.

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Nebritova Olga Alexandrovna
Bauman Moscow State Technical University, Moscow, Russia
Russia

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