Breakthrough strategies of stimulation of the cerebral lymphatics during sleep
Oxana SEMYACHKINA-GLUSHKOVSKAYA1,2, Thomas PENZEL1,3, Jurgen KURTHS1,4, Velary TUCHIN1,5,6
1Saratov State University, Astrakhanskaya str., 83, Saratov, 410012, Russia
2Physics Department, Humboldt University, Newtonstrasse 15, 12489 Berlin, Germany
3Advanced Sleep Research GmbH, Berlin, Germany, Charitéplatz 1, 10117 Berlin, Germany
4Potsdam Institute for Climate Impact Research, Telegrafenberg A31, 14473 Potsdam, Germany
5Institute of Precision Mechanics and Control, Russian Academy of Science, Saratov, Russia
6Tomsk State University, Tomsk, Russia
Abstract
There is an intensive growing body of evidence that sleep and the lymphatics play a crucial role in keeping the health of the central nervous system (CNS) via the night activation of drainage of CNS tissues and clearance of metabolites and neurotoxins. The ability to stimulate the brain drainage and clearing function during sleep might be a promising strategy in developing of innovative methods in neurorehabilitation therapy. Here we discuss that sleep is the natural driving factor for activation of the cerebral lymphatics and is a platform for development of innovative optical strategies in stimulation of drainage and cleaning function of the cerebral lymphatics. We strongly believe that this pioneering step will motivate researchers and industrial partners to develop novel promising devices for neurorehabilitaion medicine based on the night stimulation of lymphatic functions.
Speaker
Semyachkina-Glushkovskaya Oxana
Saratov State University
Russia
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