Tumor microenvironment-responsive drug delivery systems
Yi MA and Yueqing GU
Department of engineering, China pharmaceutical university, China
Abstract
It is known that most small-molecule anticancer drugs frequently suffer from poor efficacy caused by the development of drug resistance in cancer cells. Nanostructure formulations of these drugs can greatly mitigate drug resistance. However, the naked nanodrugs always cause systemic toxicity to normal organs due to non-specific drug release. Therefore, it would be an ideal strategy to encapsulate the naked nanodrugs into a biocompatible carrier for controlled release in the tumor environment. The intrinsic properties are the basis in the design of internal stimuli-responsive nanocarriers with the main focus on internal stimuli like pH value, glutathione (GSH) concentration, enzyme specific overexpression and hyperthermic. the characteristics of these triggers in pathological tissues are different from that in normal sites, thus the utility of these triggers provides new strategies in designing nanovehicles for drug delivery with higher on-target property and enhanced cellular uptake efficiency. This study aims to construct tumor microenvironment-responsive drug delivery systems to release anticancer agent in response to telomerase activity or GSH concentration. This technology will not only assist in the identification of cancer cells, its ability to intrinsically treat only cancerous cells will prevent the undesired death of healthy cells that is commonly seen using more conventional forms of chemotherapy. These findings will also help to inspire future designs of drug delivery systems that respond to cancer-specific biomolecules more accurately.REFERENCES
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Speaker
Yi MA
Department of engineering, China pharmaceutical university
China
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