Structural and Functional Optical Coherence Tomography, Technology and Applications

Abstract

Optical coherence tomography (OCT) systems with ultralong depth range, ultrawide lateral field, ultrahigh axial resolution, and enhanced contrasts are introduced. As a depth-resolved optical imaging modality with the merits of non-destruction, high-resolution, and high-speed, OCT is promising for applications in variety areas. Most recently, our group has made a step forward in OCT instrumentations. The depth range is extended to be over 200 mm, the lateral field of view is increased to be 35 mm, and the axial resolution is improved to be 0.9 μm. Angio-OCT with enhanced contrast is developed for vasculature mapping. Pump-probe OCT with molecular contrast is also developed. These novel OCT systems will open new OCT applications.
Figure 1(a) shows the developed Orthogonal Dispersive Spectral Domain OCT (OD-SDOCT) system [1-3]. Dimensional metrology of the central optical distances in assembled lenses based on this system is given in Fig. 1(b). In comparison with commercial product (LS200, Fogale), our system achieves greatly enhancement in precision (>10 x) and speed (>30 x). Uniform focusing with an extended depth range and increased working distance for OCT probe is designed and fabricated [4,5]. Figure 2(a) gives the simulated field intensity of the output beams for six typical cases of the designed probe. Microscope image of the fabricated probe and in vivo 3D OCT images of human skin at the fingertip are shown in Fig. 2(b). With merits of enhanced imaging quality and easy fabrication, the proposed probe poses great potential for important applications, especially for endoscopic imaging of human internal organs in vivo.

REFERENCES
[1] C. Wang, Z. Ding, S. Mei, H. Yu, W. Hong, Y. Yan, W. Shen, Ultralong-range phase imaging with orthogonal dispersive spectral domain optical coherence tomography, Opt. Lett. 4555-4557, 2012.
[2] W. Bao, Z. Ding, P. Li, Z. Chen, Y. Shen, C. Wang, Orthogonal dispersive spectral-domain optical coherence tomography, Opt. Exp. 10081-10090, 2014.
[3] W. Bao, Y. Shen, T. Chen, P. Li, Z. Ding, High-speed high-precision and ultralong-range complex spectral domain dimensional metrology, Opt. Exp. 11013-11022, 2015.
[4] J. Qiu, Y. Shen, Z. Shangguan, W. Bao, S. Yang, P. Li, Z. Ding, All-fiber probe for optical coherence tomography with an extended depth of focus by a high-efficient fiber-based filter, Opt. Comm. 276-282, 2018.
[5] J. Qiu, T. Han, Z. Liu, J. Meng, Z. Ding, Uniform focusing with extended depth range and increased working distance for optical coherence tomography by an ultrathin monolith fiber probe, Opt. Lett. 976-979, 2020.

Speaker

Zhihua Ding
College of Optical Science and Engineering, State Key Lab of Modern Optical Instrumentation, Zhejiang University
China

Discussion

Ask question