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Optical Microendoscopy and its applications

Ling FU1,2

1 Britton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics-Huazhong University of Science and Technology, China
2 MoE Key Laboratory for Biomedical Photonics, School of Engineering Sciences, Huazhong University of Science and Technology, China


Optical microscope is one of the most basic optical instruments and has been successfully applied to many fields. The related research has won three Nobel Prizes in modern times, covering physics and chemistry. How to use novel optical microscopy to carry out high-resolution visual monitoring inside living organisms has always been a goal pursued by optical imaging and biomedical researchers. In this talk, the recent development of optical microendsocpy in my group will be presented. The talk will introduce two unique core devices: PZT-based fiber scanner and micro-objective lens used in optical fiber confocal microscope, and explain the principles of them, as well as the first domestic medical confocal endoscopic instrument that can realize real-time visualization of mucosal cells of the human digestive tract; present the applications of microendoscopy. The developed instrument has been applied to the clinical diagnosis and treatment of gastric diseases, and its technical transformation has been applied to study brain functions (rewards, memory circuit for place navigation, etc.) shown in Fig. 1

[1] Ying Wang#, Zhi Li#, Xiaobao Liang, Ling Fu*, Four-plate piezoelectric actuator driving a large-diameter special optical fiber for nonlinear optical microendoscopy, Optics Express, 2016, 24(17): 19949-19960
[2] Li Yang, Jiafu Wang, Geng Tian, Jing Yuan, Qian Liu, Ling Fu*, Five-lens, easy-to-implement miniature objective for a fluorescence confocal microendoscope, Optics Express, 2016, 24(1): 473-484
[3] Jiafu Wang, Min Yang, Li Yang, Yun Zhang, Jing Yuan, Qian Liu, Xiaohua Hou, Ling Fu*, A confocal endoscope for cellular imaging, Engineering, 2015, 1(3): 351-360
[4] Han Qin#, Ling Fu#, *, Bo Hu#, Xiang Liao, Jian Lu, Wenjing He, Shanshan Liang, Kuan Zhang, Ruijie Li, Jiwei Yao, Junan Yan, Hao Chen, Hongbo Jia, Benedikt Zott, Arthur Konnerth*, and Xiaowei Chen*, A Visual-Cue-Dependent Memory Circuit for Place Navigation, Neuron, 2018, 99:1-9
[5] Han Qin, Jian Lu, Wenjun Jin, Xiaowei Chen, Ling Fu*, Multichannel fiber photometry for mapping axonal terminal activity in a restricted brain region in freely moving mice, Neurophotonics, 2019, 6(3): 035011


Ling FU
Britton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics-Huazhong University of Science and Technology


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