Wearable devices of multimodal optical diagnostics of microcirculatory-tissue systems: application experience in the clinic and Space

Abstract

One of the first developments of wearable devices for estimating microcirculatory-tissue systems (MTS) parameters is the analyzer "LAZMA PF" (LAZMA Ltd, Russia), which combines a multimodal approach, consisting of 2 channels - laser Doppler flowmetry (LDF) and fluorescence spectroscopy (FS). The purpose of this work is to demonstrate the successful experience of using these devices both in clinical practice and in the conditions of a space experiment.
One of the examples of using these wearable devices in the form of a distributed system on the body of patients is in endocrinology. Algorithm for the diagnostic method has been developed that allows detecting pathological changes in the blood microcirculation system, which helps doctors to objectively use these devices to assess perfusion-metabolic disorders in the biological tissues of patients' limbs. Another example is the study of the effect of pregestational type 1 diabetes on the state of MTS in patients at different stages of pregnancy. This approach allows the comparison of LDF and FS monitoring data of patients with their glucose variability monitoring data to analyze the possible effect of diurnal blood glucose changes on oxidative metabolism and blood microcirculation.
Devices were also used to evaluate the effectiveness of rehabilitation measures in patients after COVID-19. The use of these devices during both the active phase of the disease and the period of recovery of the body, allows you to determine this period more accurately and to control the effectiveness of treatment and rehabilitation.
Also, example of using wearable devices is assessing the effect of hypo-and hyperventilation yoga breathing exercises on the parameters of peripheral blood flow. Wearable analyzers allow us to develop an instrumental method for monitoring the performance of full-fledged breathing exercises and their effectiveness in rehabilitation.
An example of the successful application of new multimodal devices was a space experiment "LAZMA" aboard the ISS. The main goal of this space experiment was to study tissue respiration processes and microcirculatory blood flow in human skin under weightless conditions. For the first time, a technique has been developed for measuring MTS in the limbs of cosmonauts during the period of acute adaptation to microgravity conditions and readaptation after the completion of a space flight.
Thus, the data on the state of the MTS of the human body recorded using wearable multimodal devices in solving a variety of diagnostic tasks make it possible to assess the relationship and dynamics of oxygen utilization more comprehensively and reliably by tissues.

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Speaker

Andrey Dunaev
Orel State University
Russia

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