PORTABLE LASER DOPPLER FLOWMETRY DEVICES TO EXPLORE THE RELATIONSHIP BETWEEN SKIN BLOOD PERFUSION AND NEWLY DIAGNOSED ARTERIAL HYPERTENSION
Y.I. Loktionova1, A.A. Fedorovich2,3, E.V. Zharkikh1 , A.Yu. Gorshkov2, A.I. Korolev2,
V.A. Dadaeva2, O.M. Drapkina2, E.A. Zherebtsov1
1Research & Development Center of Biomedical Photonics, Orel State University, Orel, Russia
2FSBI “National Health and Research Center of Preventive Healthcare” of the Ministry of Health of Russia, Moscow, Russia
3FSBI SRC RF “Institute of Biomedical Problems” RAS, Moscow, Russia
Abstract
Arterial hypertension (AH) is a leading risk factor for the development of fatal cardiovascular diseases. By using portable laser Doppler flowmeters (LDF), this study examined the functional state of peripheral blood flow in men with newly diagnosed hypertension.
The study involved 89 men (44.4 8.5) with no complaints, who subjectively assessed themselves as healthy and were not taking regular medications. The participants underwent LDF on the left forearm, daily blood pressure monitoring on the left arm, echocardiography, and laboratory research methods. The men were divided into two groups based on their daily blood pressure (BP). The control group consisted of 30 men with normal blood pressure, while the AH group consisted of 59 men.
Men with AH have lower neurogenic and myogenic vasomotion amplitudes according to LDF data. Additionally, the amplitude of pulse oscillations and the perfusion efficiency of endothelial, neurogenic, myogenic, and pulse mechanisms of tissue perfusion regulation decreased. Only myogenic tone-forming mechanisms have a weak negative relationship with systolic blood pressure. A minor relationship was found between vasomotor activity of precapillary arterioles at the level of the skin's precapillaries and blood pressure in men. However, portable LDF devices can be a useful tool for selecting antihypertensive therapy and monitoring its effectiveness remotely.
The reported study was funded by the RFBR, grant number 20-08-01153.
Speaker
Yulia Loktionova
Research & Development Center of Biomedical Photonics, Orel State University, Orel, Russia
Russia
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