Monte Carlo simulation of optical radiation propagation in laser Doppler flowmetry and fluorescence spectroscopy channels of a wearable diagnostic device
Elena V. Zharkikh,1 Viktor V. Dremin,1,2 Andrey V. Dunaev,1
1 Orel State University, Orel, Russia 2 Aston University, Birmingham, UK
Abstract
The aim of the present study was to investigate the peculiarities of propagation of optical radiation of laser Doppler flowmetry (LDF) and fluorescence spectroscopy (FS) channels of a wearable diagnostic device in biological tissues based on Monte Carlo simulation. When modelling the sampling volume, the peculiarities of the geometry of the emitting and recording parts of the device were taken into account. For each of the technologies, the sampling volume was modelled for two skin types: glabrous and non-glabrous skin, characterized by different structural and functional features. For the LDF channel, the distribution of probing radiation in the biotissue was taken into account during modeling, and for the FS channel, the distribution of fluorescent radiation was additionally taken into account. Simulation results showed that for both skin types in the LDF channel implemented using a VCSEL laser with radiation at a wavelength of 850 nm, the probed tissue volume reaches the reticular dermis, and the value of the diagnostic volume is about 3-4 mm3. For the FS channel, which operates on the wavelength of 365 nm, the calculated diagnostic volume was 1.5 mm3 for nonglabrous skin type and 4.5 mm3 for glabrous skin, the probed tissue volume reaches from 30 to 70 % of the reticular dermis in each case. The obtained results can be used to better understand and improve the quality of diagnostic information obtained by the wearable LDF and FS devices.
File with abstract
Speaker
Elena Zharkikh
Research & Development Center of Biomedical Photonics, Orel State University, Orel
Russia
Discussion
Ask question
