Optical and Thermal Response of Nanoparticle-Augmented Laser-Irradiated Tissue

Abstract

In tumor cancerous treatment, laser ablation therapy is a promising method used to induce localized thermal therapy. One of the best methods to augment the heat transfer in tissue is by injecting nanoparticles to increase the photon absorption in tissue. The results of previous studies have shown that in very few cases of conventional heat transfer models, a mechanical thermo-elastic response has been considered which it can be effective in thermal damage. In order to find the thermo-mechanic interaction of laser and tissue and finding the extent of tissue thermal damage prediction, the photon transport in highly turbid media should be considered. To simulate the distribution of photons absorbed and deposited in the tissue layers, a standard Monte Carlo code is adapted and a convolution program is used to fit the Monte Carlo output to a Gaussian laser beam of known profile, beam size, and power. A set of experimental values for the optical properties of native tissue as well as tissue injected with Gold nanoparticles is being compiled from the literature. The outcome of this study would be the first step towards a clinical application in which the patient-specific condition, such as a deep tumor with an irregular shape and injected with nanoparticles, must be considered in order to the volume and extent of symmetrical thermotherapy without healthy tissue carbonization should be planed.

Key words
Laser Ablation Therapy, Monte Carlo, Nano particles, Tissue Thermal Modeling


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Speaker

Khashayar Khorsand
Isfahan University
Iran

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