Chlorine-containing drug laser delivery and photodynamic activation
Andrey V. Belikov,1,2 Yulia V. Fedorova,1 Sergey N. Smirnov,1 Anastasia D. Kozlova,1
1 ITMO University, Saint Petersburg, Russia 2 The First Pavlov State Medical University of St. Petersburg, Saint Petersburg, Russia
Abstract
Laser delivery and photodynamic activation using chlorine-containing photosensitizing drugs can significantly increase the effectiveness and quality of treatment of fungal diseases in dermatology. The possibility of microporation of the skin and nail plate by laser radiation with wavelengths placed outside the peak of the absorption band (non-resonant effect, for example, 450 nm) and close to the peak of the absorption band of photosensitizer (resonant effect, for example, 405 nm) has been demonstrated. Also, the possibility of laser delivery under the skin and nail plate of an aqueous solution modern chlorine-containing drugs by these laser radiations has been investigated. Extinction spectra of aqueous solutions of the modern chlorine-containing drugs before and after laser exposure to resonant or non-resonant radiation and photodynamic exposure with a wavelength of 654 ± 10 nm were studied in the spectral range 200÷900 nm. The influence of laser delivery and photodynamic effects on the conformational state of chlorin e6 in the chlorine-containing photosensitizing drugs was evaluated. Photodynamic light exposure in the investigated range of parameters leads to a slight decrease in the extinction of chlorine-containing drugs at the wavelengths of this light exposure, but significantly change conformational state, thereby changing the ratio of monomers and tetramers in the drugs.
Speaker
Andrey V. Belikov
ITMO University
Russia
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