HYBRID NANOPHOTONIC-MICROFLUIDIC SENSOR FOR HIGHLY SENSITIVE SURFACE MODIFICATION, LIQUIDS AND GASES ANALYSES
Aleksei Kuzin,1,2 Vasiliy Chernyshev,1 Vadim Kovalyuk,3,4 Pavel An,2,4,5 Alexander Golikov,2 Gregory Goltsman,3,5 and Dmitry Gorin 1 1 Skolkovo Institute of Science and Technology, Russia 2 Department of Physics, Moscow State Pedagogical University, Russia 3 National Research University Higher School of Economics, Russia 4 NTI Center for Quantum Communications, National University of Science and Technology MISiS, Russia 5 Russian Quantum Center, Skolkovo, Russia
Abstract
An elaboration of the photonic based sensors is the most promising direction in modern biophotonics and medicine from the point of view of real clinical applications. The highest sensitivity is demonstrated by sensors based on photonic integrated circuit (PIC). This type of sensors has been recently successfully combined with microfluidics for studying the low concentration of liquids and gases. It allows us to significantly decrease the analyte volume for analysis down to microliter units. The most significant disadvantages of such type of photonic sensors are low specificity and thermal stability. One of the methods that could be useful for improving specificity such type of problem is the layer by layer (LBL) assembly for modifying their surface with special molecules that allow to capture an analyte in the form of molecules, extracellular vesicles, and even a specific type of cells. The bovine serum albumin (BSA) and tannic acid (TA) molecules were selected for LBL assembly because on one side they form a stable LBL assembly film based on hydrogen bonds in our previous work. While the other side of both TA and BSA molecules can be used for conjugation with target molecules. Potentially, it will allow to use the developed hybrid biosensor for early diagnosis of pathological states and evaluation of treatment efficiency. Due to highly sensitive scanning opportunity in real time the developed photonic sensor device with thermal tuning is promising to create compact sensitive biosensors for clinical applications and ecology monitoring.
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Speaker
Aleksei Kuzin
Skolkovo Institute of Science and Technology
Russia
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