Ultrasound-triggerable Polylactic Acid Films with Ceftriaxone Loaded Microchamber Arrays
Ekaterina A. Mordovina, 1, Valentina O. Plastun, 1, Arkady S. Abdurashitov, 2, Pavel I. Proshin, 2, Svetlana V. Raikova, 3,4, Daniil N. Bratashov, 1, Olga A. Inozemtseva, 1, Irina Yu. Goryacheva, 1, Gleb B. Sukhorukov, 2,5, Olga A. Sindeeva, 2 1 Saratov State University, Saratov 410012, Russia 2 Skolkovo Institute of Science and Technology, Skolkovo Innovation Center, 143025, Moscow, Russia 3 Saratov Hygiene Medical Research Center of the FBSI «FSC Medical and Preventive Health Risk Management Technologies», Saratov 410022, Russia 4 Department of Microbiology, Virology, and Immunology, Saratov State Medical University, Saratov 410012, Russia 5 Queen Mary University of London, London E1 4NS, U.K.
Abstract
Microchambers array is a relatively new targeted drug delivery system that can be used both independently (as a dressing) and for functionalization of the implant's surface. The polylactic acid (PLA) “smart” films with microchamber arrays suitable for loading highly water soluble antibiotics with low molecular weight. We have demonstrated that concentration of the PLA solution influenced the film thickness, antibiotic loading efficiency, release profile, and the antibacterial effect. The efficient loading and optimal release rate are obtained for patterned films formed by the 1.5 wt % PLA in chloroform. The films produced from 1.5 and 2 wt % PLA solutions (thickness—0.42 ± 0.12 and 0.68 ± 0.16 µm, respectively) show an accelerated ceftriaxone release upon the trigger of the therapeutic ultrasound, which impacted as an expansion of the bacterial growth inhibition zone around the samples. Combining prolonged (for prevention) and triggered (for treatment) antibiotic release can allow selecting the optimal therapeutic strategy, taking into account individual patient characteristics.
This research was funded by the Grant of the President of the Russian Federation (MK-4273.2021.1.4) and Russian Federation Grant no. 14.Z50.31.0044.
Speaker
Ekaterina A. Mordovina
Saratov State University
Russia
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